St Kilda has made two changes ahead of their final game of the season, with Brandon White and Sam Fisher coming into the side to face Brisbane at Etihad Stadium on Sunday.

White, 19, will make his AFL debut after working his way into the senior side on the back of a strong month at VFL level. 

Dual best and fairest winner Fisher returns after missing last weekend's win over Richmond due to a hamstring strain.

Key forward Paddy McCartin (broken collarbone) and first-year midfielder Jade Gresham (managed) are the two exclusions.

2015 Trevor Barker Award runner-up, David Armitage, will reach the 150 game milestone on Sunday, becoming just the 55th Saint to reach that figure in the clubs 143 year history.

Armitage, 28, is one of only five St Kilda players to feature in every game this season. The Queenslander has averaged 21.3 disposals, 9.5 contested possessions, 5.8 tackles and 4.5 clearances in 2016.

Join the players and coaches at the 2016 best and fairest and celebrate an exciting season

With Tom Hickey ruled out due to a calf injury, American ruckman, Jason Holmes, gets the opportunity to add to his four career games against the Lions.

The Chicago product impressed in his first appearance of 2016 last weekend, and will face reigning Brisbane club champion, Stefan Martin, on Sunday.

Despite limited success in 2016, Justin Leppitsch's side possess some genuine stars in their engine room. 

Captain Tom Rockliff, who was an All Australian in 2014, has continued to accumulate big numbers this season, while Dayne Zorko has wrestled the mantle away from his captain to emerge as the Lions' best player this season and could be in line for a berth in the preliminary All Australian squad.

Since falling to Sydney in Round 21, effectively ending any possibility of playing in September, St Kilda has focused on winning the last two games of 2016 to finish with a winning season for the first time since 2012.

The Saints ticked off Richmond last Saturday, now the Lions await at Docklands on Sunday afternoon.

Round 23 Premiership Team
St Kilda v Brisbane
Sunday 28 August at 1.10pm
Etihad Stadium

B: S. Dempster, S. Fisher, J. Geary
HB: D. Roberton, S. Gilbert, B. White
C: L. Montagna, D. Armitage, J. Newnes
HF: M. Weller, N. Riewoldt, N. Wright
F: T. Membrey, J. Bruce, J. Billings
R: J. Holmes, S. Ross, J. Steven
Interchange: S. Savage, B. Acres, J. Lonie, D. McKenzie
Emergencies: J. Gresham, J. Sinclair, L. Pierce

IN: S. Fisher, B. White
OUT: P. McCartin, J. Gresham

NEW: B. White
MILESTONE: D. Armitage - 150 games