The Saints have made two changes to take on the Cats in Round 2 of the AFLW season at GMHBA Stadium.

Irish recruit Saoirse Lally headlines the inclusions into the Saints' lineup, playing her first game in the red, white and black since moving to Australia after a highly-respected Gaelic career.

Joining her will be veteran and inaugural Saint Darcy Guttridge, who will play her first game of the year after missing Round 1 through a back injury.

J'Noemi Anderson (hamstring) and Abby Hobson (concussion) will both miss through injury.

The clash will be broadcast live from 5pm AEST on Saturday on Fox Footy and Kayo.