THERE'S a new G-Train in town.

Power forward Caitlin Greiser has rubber-stamped her status as a Saints cult hero with a match-winning performance over Melbourne.

Under the Friday night lights at RSEA Park, the young Saints came into the final term trailing the experienced Demons outfit by just two points.

Peta Searle's side featured nine players under the age of 21, and just five days after being overrun by Adelaide at the death, the Saints turned it up a notch.

Bone-crunching tackles from Kate McCarthy and Rosie Dillon set the tone early as the 4000-strong crowd found its voice to will home the red, white and black.

The gallant Saints were still behind with eight minutes on the clock, when it was McCarthy again who lit up Moorabbin.

The crafty speedster stepped her marker before darting outside another opponent and delivering onto the chest of Greiser, who marked 50m out.

Greiser's incredible journey has taken her from National Premier League soccer to being offered scholarships from eight colleges in America, and now she was here.

This was it. This was her moment.

With the force of the faithful behind her, 'G-Train' launched a trademark long bomb from outside the arc.

The popular No. 17 wheeled away in celebration, and the roar of the crowd told the story.

The clutch major handed St Kilda a 3.1 (19) to 1.8 (14) victory, its first ever in the NAB AFL Women's Competition.

Debutant Tamara Luke was a force in defence, dominating in the air and hunting the Demons relentlessly.

Star draftee pairing Georgia Patrikios and Nicola Xenos put in a typically electric shift, while co-captain and club stalwart Rhi Watt proved a match-winner with several goal-saving acts of desperation in defence.

Young guns Isabella Shannon and Molly McDonald shone with ball in hand, and the ever-reliable Liv Vesely showed why she's a future force of the competition.

The evening was soured slightly after Melbourne suffered another serious knee injury, with Maddy Guerin being assisted off in the second quarter.

The Demons have already suffered three ACL blows this season to Ainslie Kemp, Shae Sloane and Katherine Smith.

Karen Paxman was the stand out for Melbourne with 26 disposals, bolstering her claim to the throne as the most in-form player in the league.

ST KILDA             1.0     2.0     2.0     3.1     (19)
MELBOURNE     1.4     1.5     1.8     1.8     (14)

St Kilda:
 Greiser 2, Guttridge
Melbourne: Scott

St Kilda:
 Greiser, Lucas-Rodd, Watt, Vesely, Guttridge, Drennan
Melbourne: Paxman, O'Dea, Gay, Pearce, Hore, Zanker

St Kilda:
Melbourne: Guerin (knee), Goldrick (concussion)

St Kilda:
Melbourne: Nil

Reports: Nil

Crowd: 4,012 at RSEA Park