Peta Searle has made three changes following a stirring home debut at RSEA Park.
The Saints head west to face reigning Premiers, Adelaide, with Nadia von Bertouch (inj.), Emma Mackie (inj.) and Kelly O'Neill (omitted) all sidelined.
Help will come in the form of a trio boasting experience at the top level, with former Magpie Darcy Guttridge joining ex-Kangaroos Courteney Munn and Alison Drennan for the first time in Saints colours.
Isabella Shannon and Poppy Kelly have been named on the extended bench.
St Kilda will face the high-flying Crows away this Sunday 16 February at 5.10pm AEDT.
IN: Guttridge, Munn, Drennan
OUT: Mackie and von Bertouch (inj.), O'Neill (omitted).