Bianca Jakobsson will undergo surgery this week to repair a broken collarbone.
The new Saint left the field in the second quarter following a collision in a practice match against Carlton on Saturday.
“It’s obviously really disappointing for Bianca,” Head of Women’s Football Jamie Cox said.
“She’s had a really great pre-season, so for this to happen on the eve of season proper is tough.
“That being said, Bianca has a great attitude and will no doubt attack rehab with everything she’s got.”