St Kilda has made four changes to its line-up for its clash with Box Hill at RSEA Park on Saturday.

The side is headlined by the inclusion of newest Saint Campbell Lake, who was selected at pick 7 in the AFL Mid-Season Rookie Draft on Tuesday night.

A dynamic small forward, Lake has suited up for Southport in the VFL this season already and will be looking to make an immediate impact in the red, white and black.

Tyson McKenzie has also been named for his VFL debut on Saturday, alongside AFL-listed inclusions Liam Stocker and Eamonn Armstrong, the latter of which returning after serving a two-match suspension.

Mason Wood and Isaac Keeler have both exited the side after playing in the AFL match on Thursday night, while Tyson Nagel and Jett Hartman have been omitted.

The clash will be streamed live at AFL.com.au or the official AFL app.

Be sure to stay across St Kilda's VFL Instagram channel (@stkildavfl) for content and updates.